ArticleCancer causes & control : CCC2026
Serum human papilloma virus detection following treatment of cervical cancer: prevalence and its correlation with recurrence.
Article in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
introductionThe detection of human papilloma virus (HPV) in serum after treatment for cervical cancer warrants further investigation.
objectivesTo study the prevalence of serum HPV and correlate its presence with cervical cancer recurrence.
methodsThis prospective cross-sectional study recruited 100 patients following treatment of HPV-associated cervical cancer between January 2023 and March 2024 at a tertiary care centre in South India. Patients who had completed treatment within the past 3 years were included. After obtaining consent, a one-time serum sample for HPV detection was analysed using a multiplex real-time PCR AnyplexTM II HPV HR detection assay (Seegene, Seoul, South Korea). The prevalence of serum HPV was correlated with disease recurrence and evaluated by Fisher's Exact test. The log-rank test assessed the differences in disease-free survival between cases with and without measurable serum HPV.
resultsAmong the 100 patients, the prevalence of serum HPV was 18% (18/100), with genotype 16 being found in 83.3% (15/18) of cases. There were 27 recurrences, of which 15 (55.6%) had detectable serum HPV DNA. Disease recurrence was significantly associated with serum HPV (odds ratio: 29.17, 95% confidence interval: 7.32-116.24). Higher serum HPV DNA levels, as determined by semi-quantification (2 + and 3 +), were associated with an increased hazard ratio for recurrence (58.33, CI: 6.83-498.23). Kaplan-Meier disease-free estimates revealed a significant association between recurrence and serum HPV prevalence (p = 0.000).
conclusionSerum HPV can be used in the detection of recurrence in post-treatment surveillance of cervical cancer and should be validated in a prospective, longitudinal study.
Indexed as
Identifiers
42347892What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.