Evidence map›Paper›PMID 42347880›Full record

ArticleCancer causes & control : CCC2026

Comparative risk factors among pancreatic adenocarcinoma patients vs. neuroendocrine and other pancreatic cancer patients.

Daniel C Beachler, Lauren E Parlett, Jessica L Petrick, Stephan Lanes, John Barron, David Debono, Michael J Fisch

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel C BeachlerSafety and Epidemiology, Carelon Research, 123 Justison St., Suite 200, Wilmington, DE, 19801, USA. Daniel.beachler@carelon.com.ORCID http://orcid.org/0000-0003-2788-3061
Lauren E ParlettSafety and Epidemiology, Carelon Research, 123 Justison St., Suite 200, Wilmington, DE, 19801, USA.
Jessica L PetrickSlone Epidemiology Center at Boston University, Boston, MA, USA.
Stephan LanesSafety and Epidemiology, Carelon Research, 123 Justison St., Suite 200, Wilmington, DE, 19801, USA.
John BarronSafety and Epidemiology, Carelon Research, 123 Justison St., Suite 200, Wilmington, DE, 19801, USA.
David DebonoCarelon Specialty Care Services, Indianapolis, IN, USA.
Michael J FischCarelon Specialty Care Services, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDetermine whether the risk factors for pancreatic ductal adenocarcinoma (PDAC) differ from other rare subtypes of pancreatic cancer, such as pancreatic neuroendocrine tumors (PNETs).

methodsIn this retrospective cohort (case-only) database study, the study population was pancreatic cancer patients with histology information in the Cancer Care Quality Program between July 2014 and May 2025. Multivariate logistic regression models were developed to identify independent differences in risk factors for PNETs (vs. PDACs) and other pancreatic cancers (vs. PDACs).

resultsThis study included the following incident pancreatic cancer frequencies: 7,973 PDACs, 649 PNETs, and 363 other pancreatic cancers. PNETs and other pancreatic cancer patients were younger than PDACs (mean 57 and 60 vs. 62). PNET patients were more likely to have newly diagnosed diabetes prior to their pancreatic cancer diagnosis (aOR = 1.37, 95%CI = 0.98-1.97), and less likely to smoke (aOR = 0.80, 95%CI = 0.64-1.01). PNETs and other pancreatic cancers had slightly higher baseline co-morbidity scores (Charlson) than PDACs (1.7 vs. 2.6 vs. 2.8). Other pancreatic cancers were more likely to be current alcohol drinkers (aOR = 2.86, 95%CI = 1.25-6.59). Common risk factors such as obesity and family history of pancreatic cancer were similar among the three cohorts.

conclusionsThis study suggests there may be different risk factors for rarer pancreatic cancer subtypes. Differences such as younger age and more alcohol use were noteworthy in the rarer pancreatic subtypes.

Indexed as

AdenocarcinomaCarcinoma, Pancreatic DuctalNeuroendocrine TumorsPancreatic NeoplasmsAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsDiabetesNeuroendocrine cancerPancreatic cancerRisk factorsSmoking

Identifiers

PMID42347880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.