Evidence map›Paper›PMID 42347877›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Protein phosphatase 2A impairs cardiac uptake of glucose in the mammalian heart.

Katarina Hadova, Daniel Gündel, Torsten Knieß, Peter Brust, Jan Klimas, Joachim Neumann, Ulrich Gergs

Abstract read
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katarina HadovaFaculty of Pharmacy, Comenius University in Bratislava, Odbojarov Street 10, Bratislava 3, 832 32, Slovak Republic.ORCID http://orcid.org/0000-0001-7055-9561
Daniel GündelDepartment of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Permoser Straße 15, 04813, Leipzig, Germany.ORCID http://orcid.org/0000-0001-9743-2325
Torsten KnießHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328, Dresden, Germany.ORCID http://orcid.org/0000-0002-4107-3455
Peter BrustDepartment of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Permoser Straße 15, 04813, Leipzig, Germany.
Jan KlimasFaculty of Pharmacy, Comenius University in Bratislava, Odbojarov Street 10, Bratislava 3, 832 32, Slovak Republic.ORCID http://orcid.org/0000-0002-6845-2105
Joachim NeumannInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 4, Halle, 06097, Germany.ORCID http://orcid.org/0000-0001-5018-3851
Ulrich GergsInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 4, Halle, 06097, Germany. ulrich.gergs@medizin.uni-halle.de.ORCID http://orcid.org/0000-0001-6986-485X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein phosphatase 2A (PP2A) accounts for approximately half of all serine/threonine phosphatase activity in the mammalian heart. We hypothesised that PP2A, through dephosphorylation of key regulatory enzymes, modulates cardiac glucose uptake and metabolism in vivo. Using positron emission tomography (PET), we studied the uptake of 2-[

Indexed as

GlucoseMyocardiumProtein Phosphatase 2AnimalsFluorodeoxyglucose F18HeartMaleMiceMice, TransgenicPositron-Emission TomographyProto-Oncogene Proteins c-aktFluorodeoxyglucose F18GlucoseProtein Phosphatase 2Proto-Oncogene Proteins c-akt2-[18F]fluoro- 2-deoxy-D-glucose ([18F]FDG)Glucose metabolismHeartProtein phosphatase 2ATransgenic mice

Identifiers

PMID42347877
PMCPMC13593684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.