ArticleExperimental brain research2026
Effect of physical activity on paired-pulse suppression in the somatosensory cortex after tibial nerve stimulation.
Article in Experimental brain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Paired-pulse somatosensory evoked potentials (ppSEPs) offer a robust, non-invasive measure of inhibitory interactions in the human somatosensory cortex. The impact of long-term habitual physical activity on gating mechanisms remains poorly understood. This study quantified whether regular physical activity over extended periods modulates paired-pulse suppression (PPS) after tibial nerve (TN) stimulation and whether PPS relates to weekly training volume. Fifty-nine healthy participants (29 female; 22.4 ± 3.9 years) were analyzed. Physical activity over the previous two years was assessed by questionnaire and participants were classified as physically active (PA, n = 38) if they reported more than 1.25 h/week of regular training during this period. All others were classified as non-active (NA, n = 21) participants. Single-pulse (spSEP) and ppSEPs were recorded bilaterally after suprathreshold TN stimulation using a Cz'-Fz montage. Across all participants tested, significant PPS was observed for N30/P40, P40/N50 and N50/P60 ppSEP amplitudes after both left and right TN stimulation. However, PPS and spSEP did not differ between PA and NA. PPS in right N30/P40 correlated negatively with weekly training hours in PA. No such associations were found for P40/N50 or N50/P60, nor for left-sided PPS measures. Long-term physical activity does not seem to modulate SEP components or PPS after TN stimulation. However, training volume within PA was associated with PPS of the N30/P40 amplitude after right TN stimulation, indicating a potential selective dose-dependent modulation. Longitudinal studies are needed to establish causality, explain side-specific effects, and determine the behavioral relevance for sensorimotor performance.
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