Evidence map›Paper›PMID 42347851›Full record

ArticleMetabolic brain disease2026

The comparative ameliorating effects of an amorphous formula of curcumin and α-glycosyl isoquercitrin on hippocampal dysfunction in a rat gulf war illness model.

Qian Tang, Momoka Shobudani, Yuri Sakamaki, Yuri Ebizuka, Xinyu Zou, Mio Kobayashi, Tetsuhito Kigata, Mihoko Koyanagi, Tomohiro Nakao, Makoto Shibutani

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qian TangLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.ORCID 0009-0001-8369-9798
Momoka ShobudaniLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Yuri SakamakiLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Yuri EbizukaLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Xinyu ZouLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.ORCID 0000-0001-8551-9319
Mio KobayashiLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Tetsuhito KigataCooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.ORCID 0000-0002-2219-9634
Mihoko KoyanagiGlobal Safety and Regulatory Sciences, San-Ei Gen F.F.I., Inc, 1-1-11 Sanwa-cho, Toyonaka-shi, Osaka, 561-8588, Japan.ORCID 0000-0003-2944-2438
Tomohiro NakaoEmulsion Laboratory, San-Ei Gen F.F.I., Inc, 1-1-11 Sanwa-cho, Toyonaka-shi, Osaka, 561- 8588, Japan.ORCID 0009-0009-1667-2307
Makoto ShibutaniLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. mshibuta@cc.tuat.ac.jp.ORCID 0000-0003-3417-9697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain dysfunction is a primary symptom of Gulf War illness (GWI). The present study investigated the effects of an amorphous formula of curcumin (CUR) and α-glycosyl isoquercitrin (AGIQ) on neurobehaviors and adult neurogenesis and following synaptic plasticity of produced neurons in the hippocampal dentate gyrus (DG) in a rat GWI model. Ten-week-old rats received GWI-related chemicals and restraint stress for 28 days; thereafter, animals were fed either a diet without supplement or mixed with 0.1% CUR or 0.5% AGIQ for 126 days. GWI treatment adversely affected behavioral endpoints, including novel object recognition, sucrose preference, novelty-suppressed feeding, and contextual fear conditioning. CUR ameliorated all these effects, while AGIQ caused anxiety-like behavior and improved fear extinction learning. GWI treatment downregulated NRF2-KEAP1 pathway-related genes in the DG; both phytochemicals reversed most of these changes. GWI treatment increased CD68

Indexed as

CurcuminHippocampusQuercetinAnimalsDisease Models, AnimalDoublecortin ProteinMaleNeurogenesisNeuronal PlasticityRatsRats, Sprague-DawleyCurcuminDoublecortin ProteinisoquercitrinQuercetinAlpha-glycosyl isoquercitrinCurcuminGulf War illnessNeurobehaviorNeurogenesisSynaptic plasticity

Identifiers

PMID42347851

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.