Evidence map›Paper›PMID 42347692›Full record

ArticleJournal of the American Chemical Society2026

Bioorthogonal Activation of Protein Function through a retro-Cope/Cope Elimination Cascade.

Surached Siriwongsup, Sanghyeon Lee, Yiming Guo, Conrad Wahl, Justin Kim

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Surached SiriwongsupDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.
Sanghyeon LeeDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.ORCID 0000-0001-9529-1450
Yiming GuoSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Conrad WahlDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.
Justin KimSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-4076-2005

Funding

Bioorthogonal methods for unveiling chemical reactivityR01GM149693 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Justin Kim · 2024 to 2026
$1.2M
NIGMS NIH HHS R01 GM149693
6 · The paper itself

Abstract

A bioorthogonal click-to-release reaction employing cyclooctynes and

Indexed as

HydroxylaminesProteinsClick ChemistryHydroxylamineMolecular StructureHydroxylamineHydroxylaminesProteins

Identifiers

PMID42347692
PMCPMC13352630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.