Evidence map›Paper›PMID 42347660›Full record

ArticleVaccines2026

Protective Effect Against Acute Experimental Toxoplasmosis Conferred by Intranasal Immunisation with

Carina Brito, Daniela Teixeira, Paula Goulart, Beatriz Rodrigues, Nuno Carvalho, Manuel Vilanova, Alexandra Correia, Margarida Borges

Abstract read
In one paragraph

Article in Vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carina BritoAssociate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-3973-7187
Daniela TeixeiraDepartment of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Paula GoulartDepartment of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.ORCID 0000-0001-9330-7447
Beatriz RodriguesDepartment of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.ORCID 0000-0003-2876-235X
Nuno CarvalhoDepartment of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Manuel VilanovaDepartamento de Imuno-Fisiologia e Farmacologia, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua Jorge Viterbo Ferreira, 4050-313 Porto, Portugal.ORCID 0000-0001-7007-306X
Alexandra CorreiaDepartamento de Imuno-Fisiologia e Farmacologia, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua Jorge Viterbo Ferreira, 4050-313 Porto, Portugal.ORCID 0000-0003-0408-6262
Margarida BorgesAssociate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0001-6035-4095

Funding

Fundação para a Ciência e Tecnologia 2021.06472.BDFundação para a Ciência e Tecnologia LA/P/0140/2020Fundação para a Ciência e Tecnologia UID/04378/2025
6 · The paper itself

Abstract

backgroundToxoplasmosis is a prevalent zoonotic disease worldwide, affecting approximately one-third of the global human population. Primary infection with

methodIn this work, BALB/cByJ mice were intranasally immunised with a subunit vaccine consisting of

resultThe results showed raised TGMP-specific serum IgG and intestinal IgA antibody levels, and parasite-specific IFN-γ-producing CD4

conclusionsAltogether, these results indicate that mucosal immunisation with TGMP plus CpG adjuvant is worth exploring as a vaccination approach to prevent toxoplasmosis.

Indexed as

intranasal vaccinenasal deliverysystemic sustained mucosal immunitytoxoplasmosis

Identifiers

PMID42347660
PMCPMC13308317

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.