ArticleTropical medicine and infectious disease2026
Reduced HAV IgG Seropositivity Among Unvaccinated People Living with HIV: The Weak Shield.
Article in Tropical medicine and infectious disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
People living with HIV (PLWH) represent a high-risk population for hepatitis A virus (HAV) infection, with exposure risk equal to or higher than that of the general population, particularly within adult risk networks. Anti-HAV immunoglobulin G (IgG) serves as a neutralizing antibody and is considered a key marker of protective immunity against HAV infection. However, the serologic profile of anti-HAV IgG and IgM among unvaccinated PLWH remains insufficiently characterized, especially in South China. A total of 1232 unvaccinated adults were enrolled in the study, including 800 PLWH and 432 HIV- negative controls, to evaluate the serological markers of HAV immunity. Serum anti-HAV IgG and immunoglobulin M (IgM) were measured using enzyme-linked immunosorbent assays, and demographic, immunological, and biochemical data were collected. We observed that PLWH had significantly lower anti-HAV IgG concentrations (0.27 ± 0.16 vs. 0.31 ± 0.14 ng/mL,
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