Evidence map›Paper›PMID 42347522›Full record

ArticleToxins2026

Broad-Spectrum Antiviral and Antibacterial Activity of the Scorpion Venom Peptide HP1090.

Ariel J Asuzano, Lia-Raluca Olari, Nourice Jaber, Verena Vogel, Marina S Fam, Armando A Rodríguez Alfonso, Nico Preising, Ludger Ständker, Barbara Spellerberg, Hans-Georg Breitinger and 2 more

Abstract read
In one paragraph

Article in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ariel J AsuzanoInstitute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Lia-Raluca OlariInstitute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.ORCID 0000-0001-7793-4408
Nourice JaberInstitute of Medical Microbiology and Hygiene, Ulm University Medical Center, 89081 Ulm, Germany.
Verena VogelInstitute of Medical Microbiology and Hygiene, Ulm University Medical Center, 89081 Ulm, Germany.ORCID 0000-0003-3378-5732
Marina S FamDepartment of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.ORCID 0000-0002-3908-872X
Armando A Rodríguez AlfonsoULMTeC Core Facility for Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.ORCID 0000-0001-5921-3770
Nico PreisingULMTeC Core Facility for Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.
Ludger StändkerULMTeC Core Facility for Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.ORCID 0000-0002-8436-4260
Barbara SpellerbergInstitute of Medical Microbiology and Hygiene, Ulm University Medical Center, 89081 Ulm, Germany.ORCID 0000-0001-7552-8764
Hans-Georg BreitingerDepartment of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.ORCID 0000-0003-0111-3528
Ulrike BreitingerDepartment of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.ORCID 0000-0002-3057-5919
Jan MünchInstitute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.ORCID 0000-0001-7316-7141

Funding

Deutsche Forschungsgemeinschaft 530287567Deutsche Forschungsgemeinschaft CRC1279
6 · The paper itself

Abstract

HP1090 is a short, cationic, amphipathic peptide derived from scorpion venom and previously described as a membrane-active antiviral compound. Here, we primarily characterize the antiviral activity of HP1090 and assess whether additional antibacterial effects are consistent with membrane-disruptive properties. Chemically synthesized HP1090 exhibited dose-dependent virucidal activity against multiple enveloped viruses, including herpes simplex virus type 1 and 2 (HSV-1, HSV-2), human immunodeficiency virus type 1 (HIV-1), and Zika virus (ZIKV), with IC

Indexed as

Anti-Bacterial AgentsAntiviral AgentsScorpion VenomsAnimalsBacteriaChlorocebus aethiopsHumansMicrobial Sensitivity TestsVero CellsAnti-Bacterial AgentsAntiviral AgentsScorpion VenomsAMPESKAPE pathogensHP1090lipid bilayer disruptionmembrane permeabilizationselective toxicityvenom peptide

Identifiers

PMID42347522
PMCPMC13307730

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.