Evidence map›Paper›PMID 42347521›Full record

ReviewToxins2026

Biophysical and Biochemical Assays for Screening Small Molecule Inhibitors Targeting Toxin-Ribosome Interactions.

Eric J Bryan, Vishal Vijayanand, Xiao-Ping Li, John E McLaughlin, Michael Pierce, Arkajyoti Dutta, Nilgun E Tumer

Abstract readReview
In one paragraph

Review in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric J BryanDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901, USA.
Vishal VijayanandDepartment of Bio-Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.
Xiao-Ping LiDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901, USA.
John E McLaughlinDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901, USA.ORCID 0000-0003-4511-6202
Michael PierceDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901, USA.
Arkajyoti DuttaDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901, USA.ORCID 0000-0002-4251-9332
Nilgun E TumerDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901, USA.ORCID 0000-0002-1693-2940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ribosome-inactivating proteins are a class of toxins that target eukaryotic ribosomes, inhibit protein synthesis, and ultimately induce cell death. Several of these toxins pose significant clinical and public health threats. Among these, ricin, derived from the castor bean plant (

Indexed as

Ribosome Inactivating ProteinsRibosomesAnimalsHumansRicinSmall Molecule LibrariesRibosome Inactivating ProteinsRicinSmall Molecule Librariesdrug discoverydrug screeninginfectious diseasericin toxinShiga toxin

Identifiers

PMID42347521
PMCPMC13307862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.