ArticleNeuroSci2026
Responsive Neurostimulation in Patients with a History of Viral Brain Infections-A Single-Center Experience.
Article in NeuroSci, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-resistant epilepsy (DRE) secondary to viral brain infections (VBI) may have multiple seizure foci, making it not amenable to surgical resection but could respond to responsive neurostimulation (RNS). We aimed to evaluate characteristics of DRE patients with a VBI history who did or did not respond to RNS therapy; 9 patients met criteria. Four out of 9 patients were responders to RNS therapy with ≥50% of seizure-frequency reduction at an average 39-month follow-up. Five patients were non-responders, an average 47-month follow-up. Two responders had a prior destructive surgery. Four non-responders had a prior neurosurgery including 1 focal resection, 2 vagus nerve stimulation, and 1 prior RNS. Patients in the responder group had shorter DRE duration prior to RNS placement than in the non-responder group (average 11.0 years versus 14.4 years). Three responders and four non-responders had a history of focal to bilateral tonic-clonic seizures (FBTC) pre-RNS. Post-RNS, all responders and 2 non-responders stopped experiencing FBTC. Our study demonstrates that RNS therapy could be effective in patients with DRE secondary to VBI, even if the patients failed previous surgical intervention(s). Patients in both responder and non-responder groups had reduction of convulsive seizures. These findings should be considered preliminary observations due to a small sample-size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.