Evidence map›Paper›PMID 42347155›Full record

ArticleNeuroSci2026

Neuroplasticity in Spinal Circuits Mediated by Sexual Experience and Cerebellar Lobules.

Jaime R Gutiérrez, Cristofer Zarate-Calderon, Fiorella Fadanelli-Sánchez, Abdiel A Demuner-Mendoza, René Zempoalteca-Ramírez, Luis Beltrán Parrazal, Donaji Chi-Castañeda, Luis I García

Abstract read
In one paragraph

Article in NeuroSci, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jaime R GutiérrezInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Mexico.
Cristofer Zarate-CalderonInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Mexico.ORCID 0000-0002-6039-3745
Fiorella Fadanelli-SánchezFacultad de Medicina, Campus Ciudad Mendoza, Universidad Veracruzana, Ciudad Mendoza 94740, Mexico.ORCID 0009-0008-8163-7180
Abdiel A Demuner-MendozaFacultad de Medicina, Campus Ciudad Mendoza, Universidad Veracruzana, Ciudad Mendoza 94740, Mexico.ORCID 0009-0005-5162-4715
René Zempoalteca-RamírezCentro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala 90070, Mexico.
Luis Beltrán ParrazalInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Mexico.ORCID 0000-0002-4765-9051
Donaji Chi-CastañedaInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Mexico.ORCID 0000-0002-2094-5787
Luis I GarcíaInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Mexico.ORCID 0000-0001-6967-1919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to determine whether sexual experience modulates the soleus H-reflex in male rats and to assess the specific contribution of vermis lobules 6a and 7 to cerebellar-dependent spinal plasticity.

methodsThirty-six male Wistar rats were divided into sexually inexperienced (SI) and sexually experienced (SE) groups and assigned to one of three cerebellar conditions: intact control, lobule 6a lesion, or lobule 7 lesion. SE rats underwent repeated mating sessions until they achieved efficient copulatory performance. Subsequently, targeted electrolytic lesions were made, and electromyographic recordings of the soleus H-reflex were obtained under urethane anesthesia to quantify H-wave amplitude and temporal parameters.

resultsThe global linear mixed model yielded no significant main effects of sexual experience, cerebellar condition, or their interaction on H-wave amplitude. Planned contrasts revealed a near-significant trend toward higher H-wave amplitude in sexually experienced intact animals compared with inexperienced controls (

conclusionsSexual experience appears to be associated with cerebellar-dependent modulation of soleus H-reflex excitability; lobules 6a and 7 of the cerebellar vermis contribute to this effect specifically in experienced animals. Shorter M-wave latency in experienced animals suggests parallel peripheral motor reorganization. Adequately powered confirmatory studies are needed to characterize the mechanisms underlying this association.

Indexed as

cerebellumH-reflexmotor learningsexual experiencespinal cord

Identifiers

PMID42347155
PMCPMC13304564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.