Evidence map›Paper›PMID 42347128›Full record

ArticleNeurology international2026

High Serum Glial Fibrillary Acidic Protein and Low Serum Vitamin D Levels as Risk Factors for Cognitive Impairment in Ischemic Stroke Patients.

Patricia Patricia, Anak Agung Ayu Putri Laksmidewi, Kumara Tini, Anak Agung Ayu Meidiary, Ni Made Susilawathi, Ida Ayu Sri Wijayanti

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Article in Neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Patricia PatriciaNeurology Resident, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali 80113, Indonesia.ORCID 0009-0005-8009-213X
Anak Agung Ayu Putri LaksmidewiDepartment of Neurology, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali 80113, Indonesia.ORCID 0000-0002-6372-2399
Kumara TiniDepartment of Neurology, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali 80113, Indonesia.
Anak Agung Ayu MeidiaryDepartment of Neurology, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali 80113, Indonesia.
Ni Made SusilawathiDepartment of Neurology, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali 80113, Indonesia.
Ida Ayu Sri WijayantiDepartment of Neurology, Faculty of Medicine, Udayana University, Udayana University Hospital, Bali 80361, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCognitive impairment is a common complication after ischemic stroke and affects patients' quality of life. Elevated glial fibrillary acidic protein (GFAP) and low vitamin D levels may contribute to neuroinflammation and impaired neuroplasticity, but their association with post-stroke cognitive impairment remains unclear. This study aimed to determine whether high serum GFAP and low vitamin D levels are risk factors for cognitive impairment in ischemic stroke patients.

methodsA prospective cohort study was conducted in patients with acute ischemic stroke. Serum GFAP and vitamin D levels were measured on the third day after stroke onset using an enzyme-linked immunosorbent assay (ELISA). Cognitive function was assessed two weeks after stroke onset using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina). Data were analyzed using the chi-square test and multivariate logistic regression.

resultsSeventy-six subjects were included in this study, of which 55 (72.4%) developed cognitive impairment. High serum GFAP (≥1.885 ng/mL) (RR = 1.755; 95% CI: 1.252-2.459;

conclusionsElevated serum GFAP and low vitamin D levels were independently associated with cognitive impairment after ischemic stroke and may serve as potential biomarkers for early risk stratification.

Indexed as

biomarkercognitive impairmentGFAPischemic strokevitamin D

Identifiers

PMID42347128
PMCPMC13304778

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