Comparative Study of Bacteriophage Pharmacokinetics by Different Enteral Administration Routes.

Maria Anurova, Aleksey Kuzmin, Aleksey Vorobev, Nataliya Feldman, Elena Zinurova, Andrey Aleshkin

Abstract read

In one paragraph

Article in Methods and protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Maria AnurovaSechenov First Moscow State Medical University, 8-2 Trubetskaya Street, Moscow 119048, Russia.

Aleksey KuzminSechenov First Moscow State Medical University, 8-2 Trubetskaya Street, Moscow 119048, Russia.ORCID 0009-0004-0711-6310

Aleksey VorobevFederal Budgetary Institution of Science «Moscow Research Institute of Epidemiology and Microbiology named after G. N. Gabrichevsky», Federal Service for Surveillance on Consumer Protection and Human Health (Rospotrebnadzor), 10 Admirala Makarova Street, Moscow 125212, Russia.ORCID 0000-0003-4724-2464

Nataliya FeldmanSechenov First Moscow State Medical University, 8-2 Trubetskaya Street, Moscow 119048, Russia.ORCID 0000-0001-6098-2788

Elena ZinurovaSechenov First Moscow State Medical University, 8-2 Trubetskaya Street, Moscow 119048, Russia.

Andrey AleshkinOrphan-Bio LLC, Triumphalny Proezd, 1, Sirius 354340, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of administration routes (oral and rectal) on the pharmacokinetics of Salmonella phage SE40 and Escherichia phage V18 was studied. To detect phages in biomaterial (blood, urine, and feces), the Spot-test, Gratia, and double-nested polymerase chain reaction methods were used. Systemic action of the studied phages with both routes of administration, beginning 15-30 min after administration, was demonstrated. The phages persisted for up to 24 h after both oral and rectal administration. However, the concentration in the blood was higher after oral administration, while concentrations in urine and feces were higher after rectal administration. The need to protect phages from the acidic contents of the stomach was confirmed.

Indexed as

bacteriophagesGratia methodoral route of administrationPCRpharmacokineticsrectal route of administration

Identifiers

PMID42347042

DOI10.3390/mps9030089

PMCPMC13304965

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.