Marine-Derived Fucoidan Modulates Pathways Associated with Age-Related Macular Degeneration in Cellular and Zebrafish Models.

Haqdil Hakeem Shad, Philipp Dörschmann, Samira Laura Hautmann, Johann Roider, Alexa Klettner

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In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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5 · Who and what money

Authors and funding

5 authors.

Haqdil Hakeem ShadDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.ORCID 0009-0002-7681-2753

Philipp DörschmannDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.ORCID 0009-0001-7062-9918

Samira Laura HautmannDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.

Johann RoiderDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.

Alexa KlettnerDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.ORCID 0000-0002-2709-1059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fucoidan, a sulfated polysaccharide, is known for its beneficial bioactive effects, for example antioxidant, anti-inflammatory, and vascular modulatory effects. Such a bioactive compound may also be useful for treating neurodegenerative diseases like age-related macular degeneration (AMD). Our research focuses on AMD-related pathomechanisms using primary porcine retinal pigment epithelium (RPE) cells in vitro and zebrafish (

Indexed as

Macular DegenerationPolysaccharidesAnimalsAnti-Inflammatory AgentsAntioxidantsCytokinesDisease Models, AnimalOxidative StressReactive Oxygen SpeciesRetinal Pigment EpitheliumSwineVascular Endothelial Growth Factor AZebrafishAnti-Inflammatory AgentsAntioxidantsCytokinesfucoidanPolysaccharidesReactive Oxygen SpeciesVascular Endothelial Growth Factor Aage-related macular degeneration (AMD)fucoidangene expressioninnate immunityneurodegenerative diseasesnitric oxide (NO)polysaccharideporcine retinal pigment epithelium (RPE)reactive oxygen species (ROS)vascular endothelial growth factor A (VEGF-A)zebrafish (Danio rerio)

Identifiers

PMID42346801

DOI10.3390/md24060216

PMCPMC13302583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.