ArticleMarine drugs2026
Barettin Suppresses Pancreatic Ductal Adenocarcinoma Proliferation via Topoisomerase IIα Inhibition.
Caleb A Seekins, Monique R Archuleta, Alexandria E Evans, Julia Podgorski, Jerry E Carr, Vishal Kaleeswaran, Kayla B Nguyen, Matthew E Flowers, Christopher Hulme, Todd W Vanderah and 4 more
Abstract read
In one paragraphArticle in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Caleb A SeekinsDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.ORCID 0009-0008-1110-7125 Monique R ArchuletaDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Alexandria E EvansDepartment of Chemistry and Biochemistry, College of Science, University of Arizona, Tucson, AZ 85724, USA.
Julia PodgorskiDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Jerry E CarrDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0002-8705-0080 Vishal KaleeswaranDepartment of Chemistry and Biochemistry, College of Science, University of Arizona, Tucson, AZ 85724, USA.ORCID 0009-0001-6654-6220 Kayla B NguyenDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.ORCID 0009-0005-7406-5004 Matthew E FlowersDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Christopher HulmeDepartment of Chemistry and Biochemistry, College of Science, University of Arizona, Tucson, AZ 85724, USA.
Todd W VanderahDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Paco CárdenasPharmacognosy, Department of Medicinal Chemistry, Uppsala University, 752 37 Uppsala, Sweden.ORCID 0000-0003-4045-6718 John M StreicherDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Nam Y LeeDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0002-3730-0774 Christopher CartmellDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0002-8722-9187 Funding
American Cancer Society IRG-18-161-40American Society of Pharmacognosy Research Starter GrantArizona Biomedical Research Commission RFGA2024-022-023
6 · The paper itselfAbstract
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy with few therapeutic options. Topoisomerase IIα (TOPO2α) is frequently overexpressed in PDAC and is associated with poor clinical outcomes, yet current TOPO2α-directed therapies are constrained by limited efficacy and toxicity. Barettin, a brominated indole-containing diketopiperazine isolated from the marine sponge
Indexed as
Antineoplastic AgentsCarcinoma, Pancreatic DuctalDiketopiperazinesPancreatic NeoplasmsPoriferaTopoisomerase II InhibitorsAnimalsCell Line, TumorCell ProliferationDNA-Binding ProteinsDNA Topoisomerases, Type IIHumansAntineoplastic AgentsDiketopiperazinesDNA-Binding ProteinsDNA Topoisomerases, Type IITopoisomerase II InhibitorsbarettinDNA gyrasemarine natural productpancreatic ductal adenocarcinoma (PDAC)topoisomerase IIα
Identifiers
PMID42346787
PMCPMC13302744
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