Newborn Screening for Spinal Muscular Atrophy in the Republic of Moldova: A Feasibility Study and First Steps.

Iulia Coliban, Natalia Usurelu, Igor Opalco, Sergiu Gladun, Victoria Sacara

Abstract read

In one paragraph

Article in International journal of neonatal screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Iulia ColibanHuman Molecular Genetics Laboratory, Institute of Mother and Child, MD-2062 Chisinau, Moldova.ORCID 0000-0002-8733-397X

Natalia UsureluLaboratory of Prevention of Hereditary Pathologies, Institute of Mother and Child, MD-2062 Chisinau, Moldova.ORCID 0000-0001-8685-3933

Igor OpalcoCenter for Human Reproduction and Medical Genetics, Institute of Mother and Child, MD-2062 Chisinau, Moldova.

Sergiu GladunInstitute of Mother and Child, MD-2062 Chisinau, Moldova.

Victoria SacaraHuman Molecular Genetics Laboratory, Institute of Mother and Child, MD-2062 Chisinau, Moldova.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is a severe neuromuscular disorder in which presymptomatic treatment substantially improves survival and motor outcomes, yet newborn screening for SMA remains unevenly implemented across Europe, and evidence from lower-resource health systems is needed to guide scale-up. In this study, we assessed the feasibility, diagnostic performance, and public health implications of implementing neonatal SMA screening in the Republic of Moldova within an established national newborn screening framework. A pilot genetic screening program was conducted using dried blood spot (DBS) samples collected through routine newborn screening workflows;

Indexed as

neonatal genetic screeningpilot program implementationpublic healthrare disease managementspinal muscular atrophy

Identifiers

PMID42346727

DOI10.3390/ijns12020038

PMCPMC13299184

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.