Evidence map›Paper›PMID 42346697›Full record

ArticleJournal of functional biomaterials2026

Cytomorphometric and Clinical Analysis of the Effects of Azithromycin and Platelet-Rich Fibrin on Wound Healing After Surgical Removal of an Impacted Mandibular Third Molar.

Milan Spasić, Kosta Todorović, Nikola Živković, Milica Petrović, Simona Stojanović, Ana Todorović, Branislava Stojković, Sanja Jocić, Vladan Krunić, Milan Stoiljković

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In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Milan SpasićDepartment of Oral Surgery, Dental Clinic, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.
Kosta TodorovićDepartment of Oral Surgery, Dental Clinic, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.ORCID 0000-0002-6837-2017
Nikola ŽivkovićDepartment of Pathology, Institute of Pathological Anatomy, Clinical Center, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.
Milica PetrovićDepartment of Oral Medicine and Periodontology, Dental Clinic, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.ORCID 0000-0001-6564-5131
Simona StojanovićDepartment of Oral Surgery, Dental Clinic, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.
Ana TodorovićDepartment of Orthodontics, Dental Clinic, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.ORCID 0000-0002-7107-0183
Branislava StojkovićDepartment of Preventive and Pediatric Dentistry, Dental Clinic, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.ORCID 0000-0002-4375-7519
Sanja JocićDepartment of Oral Surgery, Dental Clinic, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.
Vladan KrunićDepartment of Oral Surgery, Dental Clinic, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.ORCID 0009-0002-8807-3943
Milan StoiljkovićDepartment of Pharmacology, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.

Funding

Internal project, of Medical faculty University of Niš 47Ministry of Science, Technological Development and Innovation (Serbia) 45
6 · The paper itself

Abstract

Impacted mandibular third molars present a common challenge in oral surgery, often associated with postoperative complications such as delayed healing and periodontal defects; therefore, optimizing adjunctive therapies is clinically important. In this study, we aimed to evaluate the efficacy of platelet-rich fibrin (PRF) and preoperative azithromycin in modulating inflammation and enhancing wound healing following surgical extraction of impacted mandibular third molars. In this prospective clinical study, healthy subjects aged 18-50 years were randomly assigned to three groups: a control group receiving standard postoperative amoxicillin therapy, a PRF group receiving PRF with standard therapy, and a PRF-plus-azithromycin group receiving PRF, standard therapy, and a single preoperative dose of azithromycin. Clinical parameters were assessed and cytomorphometric analysis was performed preoperatively and postoperatively. Clinical parameters generally improved over time in all groups (

Indexed as

Azithromycinbiomaterialscytomorphometric analysisPRFregenerative dentistrywisdom tooth

Identifiers

PMID42346697
PMCPMC13301220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.