Research Progress and Translational Perspectives of Piezoelectric Materials in Dental Implant Surface Engineering.

The long-term stability of dental implants is limited by multiple factors, including peri-implant infection, impaired osseointegration, and poor soft tissue sealing. Compared with conventional passive surface modification strategies, piezoelectric materials can convert mechanical energy into local electrical signals under occlusal loading, cell traction, or ultrasonic stimulation. With the aid of defect engineering, heterostructure construction, and co-catalytic design, these materials can also induce the generation of reactive oxygen species and reactive nitrogen species, thereby enabling on-demand antibacterial activity. This review systematically summarizes the bioelectric basis of bone tissue and clarifies how piezoelectricity and piezocatalysis may be used in dental implant surface engineering. Their applications are discussed in terms of antibiofilm and antibacterial activity, osteogenesis and osseointegration, osteoimmunomodulation, soft tissue healing, and temporally programmed therapy. In addition, this review also discusses issues that remain unresolved, such as polymer-based composite systems, realistic activation windows, evaluation standards, device-material integration, and multi-omics validation. Overall, piezoelectric surface engineering is evolving from a single osteogenesis-oriented strategy into an integrated platform that coordinates infection control, immune remodeling, and osseointegration. However, the actual effectiveness of its clinical application still needs to be determined through more rigorous mechanism analysis, long-term stability assessment, biosafety assessment, and standardized preclinical research.