ReviewJournal of personalized medicine2026
Extrachromosomal DNA Amplification as a Prognostic Factor for Cancer.
Review in Journal of personalized medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
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Abstract
backgroundExtrachromosomal DNA (ecDNA) amplification represents a distinct mechanism of genomic instability in cancer, increasingly recognized for its role in aggressive disease progression. This review examines how ecDNA drives tumour evolution and assesses its potential as both a prognostic marker and therapeutic target.
methodsThe authors integrate findings from multiple detection platforms-including FISH, whole-genome sequencing, and specialized reconstruction algorithms-and present data across diverse cancer types; no preregistration is noted, and no animal studies are included.
resultsecDNA consists of circular, acentric DNA elements carrying high-copy oncogene amplifications (such as
conclusionsThe authors conclude that ecDNA amplification serves as a credible adverse prognostic indicator and holds promise for refining risk stratification and guiding treatment strategies. However, they stress that clinical adoption remains constrained by the absence of standardized, scalable, and reproducible detection.
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