Evidence map›Paper›PMID 42346596›Full record

ReviewJournal of personalized medicine2026

Clinical Significance of Non-Invasive Skin Autofluorescence Measurement and AI Applications in Patients with Diabetic Foot Ulcers: A Scoping Review.

Cosimo Aliani, Piergiorgio Francia, Cosimo Nardi, Alessandra De Bellis, Roberto Anichini, Leonardo Bocchi

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cosimo AlianiDepartment of Information Engineering, University of Florence, Via di Santa Marta 3, 50139 Florence, Italy.ORCID 0000-0002-2023-3464
Piergiorgio FranciaDepartment of Information Engineering, University of Florence, Via di Santa Marta 3, 50139 Florence, Italy.ORCID 0000-0001-5176-1449
Cosimo NardiDepartment of Experimental and Clinical Biomedical Science, Viale Giovanni Battista Morgagni 50, 50134 Florence, Italy.ORCID 0000-0002-5489-7824
Alessandra De BellisDepartment of Diabetology, S.M. Annunziata Hospital of Bagno a Ripoli, Via Antella 58, 50012 Florence, Italy.
Roberto AnichiniDepartment of Internal Medicine, Diabetes Unit-San Jacopo Hospital of Pistoia, Via Ciliegiole 97, 51100 Pistoia, Italy.ORCID 0000-0002-8227-9388
Leonardo BocchiDepartment of Information Engineering, University of Florence, Via di Santa Marta 3, 50139 Florence, Italy.ORCID 0000-0001-5109-3399

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging optical technologies may offer new opportunities for the non-invasive assessment of diabetic foot ulcers (DFUs), but the role of artificial intelligence (AI)-assisted autofluorescence-based approaches remains unclear. This scoping review aimed to map and summarise the published evidence on AI-assisted analysis of autofluorescence/fluorescence-based signals for DFU assessment and management. We searched Scopus, Web of Science, Embase, PubMed, CINAHL, Google Scholar, and the SPIE Digital Library, and also considered conference proceedings. We included English-language studies published between 2010 and October 2025. Of 197 records identified through database searching, 22 full-text articles were assessed for eligibility, and 5 studies met the inclusion criteria. Four studies focused on infection-related applications, specifically bacterial burden detection and Gram-type classification, whereas one study investigated tissue oxygenation estimation using a related optical imaging approach. All included studies were published between 2022 and 2025, were conducted in India, and four of the five evaluated the same device family or related variants. Overall, the evidence base was limited, geographically restricted, and technologically narrow. In addition, reporting of participant characteristics and AI methodology was often incomplete, with several studies relying on embedded proprietary or insufficiently described algorithmic components. Taken together, the available literature supports early proof-of-feasibility in restricted and largely device-specific evaluation settings rather than robust evidence of broad clinical validity, implementation readiness, or routine-care utility. Larger, more diverse, and independently validated studies with standardised acquisition procedures and more transparent AI reporting are needed before these approaches can be meaningfully evaluated for routine DFU care.

Indexed as

artificial intelligenceautofluorescence imagingbacterial infectiondiabetic foot ulcermachine learningmultispectral imagingwound autofluorescence

Identifiers

PMID42346596
PMCPMC13301743

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.