Patients with Restless Leg Syndrome Have Lower Coronary Flow Velocity Reserve Compared to Healthy Controls: Case-Control Study.

Göksel Güz, Rasim Onur Karaoğlu, Sezen Kumaş Solak, Serdar Demirgan

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Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Göksel GüzDepartment of Cardiology, Medicana International Hospital, 34520 Istanbul, Turkey.

Rasim Onur KaraoğluDepartment of Anesthesiology and Reanimation, Bagcılar Training Research Hospital, University of Health Sciences, 34200 Istanbul, Turkey.

Sezen Kumaş SolakDepartment of Anesthesiology and Reanimation, Bagcılar Training Research Hospital, University of Health Sciences, 34200 Istanbul, Turkey.

Serdar DemirganDepartment of Anesthesiology and Reanimation, Bagcılar Training Research Hospital, University of Health Sciences, 34200 Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRestless leg syndrome (RLS) has been associated with an increased risk of vascular disorders, which suggests that endothelial dysfunction plays an important role in the pathogenesis of RLS. In this study, we aimed to evaluate coronary endothelial dysfunction in RLS patients using coronary flow velocity reserve (CFVR) and compared it with healthy controls. METHODOLOGY: In this study, the participants were divided into two groups as group RLS (

resultsIn the group RLS, CFVR was measured lower than healthy controls (

conclusionsIn this exploratory study, RLS patients had lower CFVR compared with healthy controls and a negative correlation was observed between RLS severity and CFVR. These findings warrant confirmation in larger, prospectively designed studies with multivariable adjustment. Therefore, we think that it may be beneficial to follow-up patients with RLS in terms of coronary heart disease. CLINICAL TRIAL NUMBER: not applicable.

Indexed as

coronary flow velocity reservecoronary heart diseaseendothelial dysfunctionrestless leg syndrome

Identifiers

PMID42346490

DOI10.3390/jcdd13060270

PMCPMC13300790

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