Evidence map›Paper›PMID 42346398›Full record

ArticleMetabolites2026

Gα

Evelyn A Bates, Zachary A Kipp, Wang-Hsin Lee, Genesee J Martinez, Sally N Pauss, Philipp E Scherer, Terry D Hinds

Abstract read
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evelyn A BatesDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID 0000-0002-4157-2481
Zachary A KippDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID 0000-0001-7344-7469
Wang-Hsin LeeDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID 0000-0001-5258-8318
Genesee J MartinezDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID 0000-0002-4593-7708
Sally N PaussDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID 0000-0002-7365-7172
Philipp E SchererTouchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-0680-3392
Terry D HindsDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID 0000-0002-7599-1529

Funding

The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7M
White Adipose Tissue Physiology, Mitochondrial Function and AdiponectinR01DK099110 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PHILIPP E SCHERER · 2013 to 2026
$6.7M
Metabolic Benefits of Leptin ReductionR01DK127274 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST, PHILIPP E SCHERER · 2021 to 2026
$5.1M
Novel Liver Signaling Pathways Controlling AdiposityR01DK121797 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HINDS, TERRY D · 2020 to 2024
$2.2M
Physiological Role of Dedifferentiating Dermal Adipose TissueR01DK131537 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SCHERER, PHILIPP E · 2022 to 2025
$2.1M
Neurobehavioral mechanisms underlying xylazine and fentanyl co-use and withdrawalR01DA058933 · NIDA · UNIVERSITY OF KENTUCKY · PI Cassandra D Gipson-Reichardt, Terry D Hinds · 2023 to 2026
$2.0M
American Heart Association 25PRE1374495National Heart Lung and Blood Institute F31HL170972National Heart Lung and Blood Institute F31HL175979National Heart Lung and Blood Institute R01HL174521NIA NIH HHS P01AG051459NIDA NIH HHS R01DA058933NIDDK NIH HHS R01DK099110NIDDK NIH HHS R01DK121797NIDDK NIH HHS R01DK127274NIDDK NIH HHS R01DK131537NIDDK NIH HHS R01DK55758
6 · The paper itself

Abstract

BACKGROUND/

objectivesSignaling mediators of PPARγ influence pathways involved in adipogenesis, lipid storage, inflammation, energy-related processes, and glucose utilization. Recent research indicates that PPARγ coregulators, recruited or released during ligand binding, govern specific gene pathways. It was recently discovered that Gα

methodsTo explore Gα

resultsThe absence of Gα

conclusionsThese findings support Gα

Indexed as

coregulatorCRISPRdiabetesGPCRG protein-coupled receptorinflammationkinomemitochondrianuclear receptorobesity

Identifiers

PMID42346398
PMCPMC13304297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.