Evidence map›Paper›PMID 42346219›Full record

Trial reportCurrent oncology (Toronto, Ont.)2026

Targeting Phosphatidylserine in Advanced Gastric and Gastroesophageal Junction Adenocarcinomas: A Phase 2 Trial of Bavituximab Plus Pembrolizumab with Biomarker-Correlated Outcomes.

Panagiotis Ntellas, Haeseong Park, Kerry Culm, Jeeyun Lee, Hagop Youssoufian, Colleen Mockbee, Mark Uhlik, Laura Benjamin, Ian Chau

Abstract readClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Panagiotis NtellasDepartment of Medicine, The Royal Marsden Hospital, Downs Road, Sutton SM25PT, UK.ORCID 0000-0003-1708-3861
Haeseong ParkDivision of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kerry CulmOncXerna Therapeutics, Waltham, MA 02451, USA.
Jeeyun LeeDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
Hagop YoussoufianOncXerna Therapeutics, Waltham, MA 02451, USA.
Colleen MockbeeOncXerna Therapeutics, Waltham, MA 02451, USA.
Mark UhlikOncXerna Therapeutics, Waltham, MA 02451, USA.
Laura BenjaminOncXerna Therapeutics, Waltham, MA 02451, USA.
Ian ChauDepartment of Medicine, The Royal Marsden Hospital, Downs Road, Sutton SM25PT, UK.ORCID 0000-0003-0286-8703

Funding

OncXerna Therapeutics Sponsor
6 · The paper itself

Abstract

Advanced gastric and gastroesophageal junction (gastric/GOJ) adenocarcinomas have poor outcomes, and the benefit of immune checkpoint inhibitors (CPIs) remains limited. Bavituximab is a phosphatidylserine-targeting monoclonal antibody that modulates the immune and vascular tumour microenvironment. This Phase 2, open-label, multinational study evaluated bavituximab plus pembrolizumab in previously treated advanced gastric/GOJ. Patients were stratified into CPI-naïve (

Indexed as

AdenocarcinomaAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsEsophageal NeoplasmsEsophagogastric JunctionPhosphatidylserinesStomach NeoplasmsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedTreatment OutcomeAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedbavituximabBiomarkers, TumorpembrolizumabPhosphatidylserinesbavituximabbiomarkersgastric adenocarcinomagastroesophageal adenocarcinomagastroesophageal junction adenocarcinomasGOJimmune checkpoint inhibitorsimmunomodulationimmunotherapypembrolizumabphosphatidylserineTMEtumour microenvironment

Identifiers

PMID42346219
PMCPMC13298944

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.