ArticleCurrent oncology (Toronto, Ont.)2026
Clinical Features and Key Prognostic Indicators of Growth Hormone-Secreting Pituitary Adenomas: A Retrospective Study of 344 Cases.
Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIn growth hormone-secreting pituitary adenomas (GHPA), postoperative hormonal non-remission and tumor recurrence determine clinical prognosis. Notably, some patients exhibit persistent hormonal abnormalities despite intraoperative gross total resection (GTR). This study systematically analyzes the prognostic risk factors in GHPA.
methodsThis study collected clinical information from 344 GHPA patients. Univariate and multivariate regression analyses were performed to screen independent risk factors for hormonal non-remission, tumor recurrence, and hormonal non-remission after GTR. Nomograms were established for predicting hormonal non-remission and 3-/5-year recurrence probabilities. Subgroup comparisons were performed to further analyze significant risk factors.
resultsMultivariate Logistic regression identified recurrent cases (
conclusionsPatients with high preoperative GH levels, higher Knosp grades, and recurrence often have a poorer prognosis after treatment. These results support stratified postoperative management and individualized monitoring of GHPA patients.
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