Evidence map›Paper›PMID 42346129›Full record

ArticleCells2026

The Reconstitution of the Macrophage Niche Reveals Dynamic Transcriptional and Renal Macrophage-Epithelial Communication Networks.

Mohammad Islamuddin, Lixuan Ji, Yilin Chen, Kejing Song, Calder R Ellsworth, Jack Rappaport, Chenxiao Wang, Shumei Liu, Jay Kolls, Xiaojiang Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mohammad IslamuddinTulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0002-4929-8931
Lixuan JiDepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Yilin ChenTulane National Biomedical Research Center, Covington, LA 70433, USA.
Kejing SongDepartments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0003-0976-5109
Calder R EllsworthTulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0001-7111-525X
Jack RappaportDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Chenxiao WangTulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0001-7950-9288
Shumei LiuTulane National Biomedical Research Center, Covington, LA 70433, USA.
Jay KollsDepartments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0001-5151-6304
Xiaojiang XuDepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0001-5758-6581
Xuebin QinTulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0001-9875-983X

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
NIH HHS P51 OD011104
6 · The paper itself

Abstract

Renal-resident macrophages (RMs) are essential regulators of kidney homeostasis and repair, yet the mechanisms governing RM niche regeneration after acute depletion remain poorly defined. To overcome these limitations, we have developed an inducible human CD59- intermedilysin (hCD59-ILY) ablation system, enabling rapid, specific, and reversible depletion of targeted macrophage populations, and subsequent replenishment of RMs, followed by longitudinal scRNA-seq analysis of kidneys at baseline and days 1, 3, and 7 post-ablation. RM ablation triggered a rapid and sustained upregulation of

Indexed as

Cell CommunicationEpithelial CellsKidneyMacrophagesTranscription, GeneticAnimalsGene Regulatory NetworksHumansMiceOsteopontinRegenerationSignal TransductionOsteopontincell–cell communication networksepithelial–immune crosstalkniche regenerationosteopontinproximal tubule epithelial cellsrenal macrophages

Identifiers

PMID42346129
PMCPMC13297203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.