Evidence map›Paper›PMID 42346125›Full record

ReviewCells2026

Cone Opsins and Inherited Retinal Disease.

Maya Tang, Paul S-H Park

Abstract readReview
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maya TangDepartment of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0009-0001-4997-9163
Paul S-H ParkDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-1638-9693

Funding

PHOTOTRANSDUCTION IN HEALTH AND DISEASE - Administrative SupplementR01EY021731 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Paul S Park · 2011 to 2026
$6.5M
NEI NIH HHS R01 EY021731NIH HHS 2R01EY021731-15
6 · The paper itself

Abstract

Opsins are the light receptors in retinal rod and cone photoreceptor cells that initiate vision in response to a light stimulus. Rhodopsin is the opsin in rods, and the influence of mutations that disrupt its structure and function has been characterized in detail. Less is known about cone opsins, the opsins in cones, and their gene arrays. Cones are responsible for color vision and high visual acuity and operate under most lighting conditions. There are up to three types of cone opsins (L-, M-, and S-opsin) in most vertebrates, each defined by their distinct spectral sensitivities. Disruptions in the cone opsin gene array cause a variety of inherited retinal disorders, including blue cone monochromacy, Bornholm eye disease, and tritan color vision deficiency. In this review, we discuss what is known about cone opsin mutations and the inherited cone dysfunctions that they cause. We also present the available mouse models that are being used to better understand the pathophysiology promoted by cone opsin defects.

Indexed as

Cone OpsinsRetinal Cone Photoreceptor CellsRetinal DiseasesAnimalsDisease Models, AnimalHumansMutationCone Opsinscolor blindnesscone opsindeuteranopiainherited retinal diseasemouse modelsphotoreceptor cellprotanopiatritanopia

Identifiers

PMID42346125
PMCPMC13297016

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.