Evidence map›Paper›PMID 42346084›Full record

ArticleCells2026

Cholinergic Differentiation of Human iPSCs Reveals Early APOE4-Driven Dysregulation of Neuronal Markers, Synaptogenesis and Inflammatory Responses.

Nele Johanne Czaniera, Wiebke Schulten, Katja Nowak, Diana Pschik, Jonas Joneleit, Barbara Kaltschmidt, Christian Kaltschmidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nele Johanne CzanieraDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Wiebke SchultenDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Katja NowakDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Diana PschikDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.
Jonas JoneleitForschungsverbund BioMedizin Bielefeld, Ostwestfalen-Lippe (OWL) (FBMB e.V.), 33611 Bielefeld, Germany.
Barbara KaltschmidtForschungsverbund BioMedizin Bielefeld, Ostwestfalen-Lippe (OWL) (FBMB e.V.), 33611 Bielefeld, Germany.
Christian KaltschmidtDepartment of Cell Biology, University of Bielefeld, 33615 Bielefeld, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by progressive memory impairment and cognitive decline. The

Indexed as

Apolipoprotein E4BiomarkersCell DifferentiationCholinergic NeuronsInduced Pluripotent Stem CellsInflammationNeurogenesisSynapsesAlzheimer DiseaseApolipoprotein E3HumansTumor Necrosis Factor-alphaApolipoprotein E3Apolipoprotein E4BiomarkersTumor Necrosis Factor-alphaAlzheimer’s diseaseAPOEAPOE3APOE4cholinergic neuronshiPSCs-derived neuronsneuroinflammationneuronal differentiationTNF-α

Identifiers

PMID42346084
PMCPMC13296407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.