Evidence map›Paper›PMID 42345888›Full record

ReviewBiosensors2026

SPR Sensing: From Biomolecular Interactions to Cell-Based Analysis.

Petia Genova-Kalou, Evdokiya O Hikova, Todor Kereziev, Petar T Kolev, Vihar Mankov, Hristo Kisov, Anna Atanasova, Georgi L Dyankov

Abstract readReview
In one paragraph

Review in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Petia Genova-KalouNational Center of Infectious and Parasitic Diseases, 44A Gen. Stoletov Blvd., 1233 Sofia, Bulgaria.ORCID 0000-0003-3820-3658
Evdokiya O HikovaInstitute of Optical Materials and Technologies "Acad. J. Malinowski" (IOMT), Bulgarian Academy of Sciences (BAS), 109 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.ORCID 0000-0003-3014-8535
Todor KerezievCentral Laboratory of Applied Physics, Bulgarian Academy of Sciences, 61 Sankt Petersburg Blvd., 4000 Plovdiv, Bulgaria.ORCID 0009-0002-5086-730X
Petar T KolevInstitute of Optical Materials and Technologies "Acad. J. Malinowski" (IOMT), Bulgarian Academy of Sciences (BAS), 109 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Vihar MankovInstitute of Optical Materials and Technologies "Acad. J. Malinowski" (IOMT), Bulgarian Academy of Sciences (BAS), 109 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Hristo KisovCentral Laboratory of Applied Physics, Bulgarian Academy of Sciences, 61 Sankt Petersburg Blvd., 4000 Plovdiv, Bulgaria.ORCID 0000-0002-4980-0864
Anna AtanasovaInstitute of Optical Materials and Technologies "Acad. J. Malinowski" (IOMT), Bulgarian Academy of Sciences (BAS), 109 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Georgi L DyankovInstitute of Optical Materials and Technologies "Acad. J. Malinowski" (IOMT), Bulgarian Academy of Sciences (BAS), 109 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.ORCID 0000-0003-0927-0659

Funding

Bulgarian National Science Fund КП-06-Н789/14.12.2023Bulgarian Science Fund, Bulgaria КП-06-Н789/14.12.2023
6 · The paper itself

Abstract

Surface plasmon resonance (SPR) is a key tool for quantifying biomolecular interactions, and its use in studying interacting components outside cellular systems is well-established. Over the past 20-25 years, cell-based SPR techniques have emerged, with the promise of precise detection of molecular interactions within their normal physiological environment. Research on a wide variety of biological samples, which requires the detection of numerous parameters, has led to the development of a broad range of SPR techniques. This review aims to trace the chronological development of these techniques and the factors that have driven them. In this context, particular focus is given to grating-coupled SPR applied to cell assays. Its specific capabilities are examined, and the respective advantages and disadvantages of other SPR techniques are discussed based on the results obtained from studying specific biological objects. Finally, we venture to predict the promising SPR techniques, as well as the areas of application in which significant results can be expected.

Indexed as

Biosensing TechniquesSurface Plasmon ResonanceAnimalsHumanscell-based analysiscytotoxicitymorphologypharmacokineticsproliferationsurface plasmon resonance

Identifiers

PMID42345888
PMCPMC13297553

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.