ArticleBiology2026
Effects of Type I Diabetes Mellitus and Masticatory Loading on Mandibular Growth in Growing Rats: A Longitudinal CBCT Study.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCraniofacial growth is regulated by a complex interaction of genetic, functional, and systemic metabolic factors. Mechanical loading generated during mastication plays a fundamental role in mandibular development through bone modeling and remodeling mechanisms. In contrast, Type I diabetes mellitus is associated with impaired bone metabolism, which may compromise skeletal growth. Although the independent effects of functional loading and metabolic disorders on bone tissue have been widely investigated, their combined influence on mandibular development remains insufficiently understood.
objectiveThis study primarily aimed to evaluate the effect of Type I diabetes mellitus on mandibular growth in growing rats and, secondarily, to assess the impact of dietary consistency (hard versus soft food) on mandibular development under diabetic and non-diabetic conditions, as well as determine whether diabetes modifies the mandibular adaptive response to increased masticatory loading. MATERIALS AND
methodsAn experimental animal study was conducted using twenty-four male Wistar rats aged one month. The animals were randomly allocated into four groups according to metabolic status (control or diabetic) and dietary consistency (hard or soft diet). Type I diabetes mellitus was experimentally induced in the relevant groups using streptozotocin. All animals underwent cone beam computed tomography (CBCT) scanning at baseline (Day 1) and at the end of the experimental period (Day 28). Linear measurements were obtained using specialized software following euthanasia. Two-way ANOVA was used to evaluate the effects of diabetes, diet, and their interaction, using appropriate post hoc tests for multiple comparisons. Categorical variables were analyzed using the chi-square test. A
resultsLongitudinal morphometric analysis demonstrated that Type I diabetes mellitus significantly impaired mandibular growth. Diabetic animals exhibited reduced growth rates and smaller final mandibular dimensions compared with controls. Hard diet intake significantly enhanced mandibular development in control animals, reflecting a strong adaptive response to increased functional loading. However, this osteogenic response was markedly attenuated in diabetic rats. Under soft-diet conditions, differences between control and diabetic groups were diminished, indicating that reduced mechanical stimulation limits adaptive growth responses. Significant interaction effects between diabetes and dietary consistency were observed in several morphometric parameters, particularly those related to mandibular body length, ramus height, and condylar position.
conclusionsType I diabetes mellitus exerts a detrimental effect on mandibular growth in growing rats and compromises the adaptive response of craniofacial structures to mechanical loading. Although a hard diet functions as a potent osteogenic stimulus, its growth-promoting effect is substantially reduced in the presence of metabolic dysfunction.
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