Role of Innate Lymphoid Cells in Chronic Rhinosinusitis: Insights from Tissue and Peripheral Blood Flow Cytometric Analysis.

Rina Hoffmann, Franziska Rombach, Jens Grimm, Agmal Scherzad, Stephan Hackenberg, Pascal Ickrath

Abstract read

In one paragraph

Article in Advances in respiratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Rina HoffmannDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Wuerzburg, 97074 Wuerzburg, Germany.

Franziska RombachDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Wuerzburg, 97074 Wuerzburg, Germany.

Jens GrimmDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Wuerzburg, 97074 Wuerzburg, Germany.ORCID 0000-0002-5902-4133

Agmal ScherzadDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Wuerzburg, 97074 Wuerzburg, Germany.ORCID 0000-0003-3396-5995

Stephan HackenbergDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Wuerzburg, 97074 Wuerzburg, Germany.ORCID 0000-0001-6995-1849

Pascal IckrathDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Wuerzburg, 97074 Wuerzburg, Germany.ORCID 0000-0001-8775-1330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Innate lymphoid cells (ILCs) are potent cytokine producers that regulate local immune responses in tissues. Natural killer (NK) cells belong to group 1 ILCs and play an important role in tumor clearance and defense against intracellular pathogens. ILC2 and 3 have been implied in allergic responses and other chronic inflammatory diseases. The role of these cells in the pathogenesis of chronic rhinosinusitis (CRS) is not completely understood. There are changes in the cellular infiltrate in the mucosa of patients with CRS with and without polyps. The aim of this study was to characterize the number and phenotype of NK cells, ILC2s and ILC3s in patients with CRS. (2) Methods: Tissue samples were collected from patients with CRS with and without nasal polyps who were undergoing nasal sinus surgery as well as control patients who were undergoing surgery due to non-inflammatory reasons. Lymphocytes were isolated from the tissues using mechanical and enzymatic dissociation. Peripheral blood lymphocytes were obtained from the same patients. All cells were examined by multicolor flow cytometry. NK cells were analyzed for the distribution of CD56

Indexed as

Immunity, InnateKiller Cells, NaturalLymphocytesRhinitisRhinosinusitisSinusitisAdultChronic DiseaseFemaleFlow CytometryHumansMaleMiddle AgedNasal Polypschronic rhinosinusitis with nasal polypschronic rhinosinusitis without nasal polypsinnate lymphoid cells

Identifiers

PMID42345640

DOI10.3390/arm94030035

PMCPMC13296213

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