Evidence map›Paper›PMID 42345602›Full record

ArticleOncoimmunology2026

Early neutrophil infiltration promotes TRIMELVax-induced antitumor immunity by linking local inflammation to tumor control.

Amarilis Pérez-Baños, María Alejandra Gleisner, Andrés Tittarelli, Daniela Tapia, María Elisa Cuevas, Antonia Mardonez, Fabián Tempio, Rosario Astaburuaga-García, Iván Flores, Cristian Pereda and 8 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Amarilis Pérez-BañosInterdisciplinary Nucleus of Pharmacology and Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
María Alejandra GleisnerInterdisciplinary Nucleus of Pharmacology and Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.ORCID 0000-0002-4172-9709
Andrés TittarelliInstituto Universitario de Investigación y Desarrollo Tecnológico (IDT), Universidad Tecnológica Metropolitana, Santiago, Chile.ORCID 0000-0003-4129-9734
Daniela TapiaInterdisciplinary Nucleus of Pharmacology and Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
María Elisa CuevasInterdisciplinary Nucleus of Pharmacology and Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Antonia MardonezInterdisciplinary Nucleus of Pharmacology and Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Fabián TempioInterdisciplinary Nucleus of Pharmacology and Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Rosario Astaburuaga-GarcíaInstitute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Iván FloresDepartment of Basic and Clinical Oncology, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Cristian PeredaInterdisciplinary Nucleus of Pharmacology and Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Álvaro LladserCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.ORCID 0000-0002-5576-1478
Fermín E GonzálezMillennium Institute for Immunology and Immunotherapy, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Sebastián ValenzuelaCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Micaela RiccaCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
María Inés BeckerFundación Ciencia y Tecnología para el Desarrollo (FUCITED), Santiago, Chile.
Nils BlüthgenInstitute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Adnane AchourScience for Life Laboratory, Department of Medicine, Karolinska Institutet, & Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Flavio Salazar-OnfrayInterdisciplinary Nucleus of Pharmacology and Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.ORCID 0000-0002-1848-5697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhancing innate-adaptive immune crosstalk is key for improving cancer vaccine efficacy. TRIMELVax is a heat shock-conditioned whole-tumor-cell vaccine combining xenogeneic melanoma cell lysate, syngeneic B16F10 melanoma cell lysate, and

Indexed as

Cancer VaccinesMelanoma, ExperimentalNeutrophil InfiltrationNeutrophilsAnimalsCell Line, TumorCytokinesDendritic CellsFemaleInflammationMiceMice, Inbred C57BLCancer VaccinesCytokinescancer vaccinedendritic cellImmunotherapymelanomaneutrophiltumor microenvironment

Identifiers

PMID42345602
PMCPMC13313172

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.