Evidence map›Paper›PMID 42345566›Full record

ArticleMicrobiology spectrum2026

Urine sample for HPV detection in men: is it a valid and non-invasive diagnostic alternative?

Arianna Sucato, Nicola Serra, Michela Buttà, Leonardo Di Gregorio, Manfredi Del Sordo, Daniela Pistoia, Alberto Firenze, Maurizio Soresi, Gabriele Tulone, Giuseppina Capra

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arianna SucatoDepartment of Health Promotion, Mother and Child Care, Internal Medicine, Medical Specialties (PROMISE) G. D'Alessandro, University of Palermo, Palermo, Italy.ORCID 0009-0007-2709-5037
Nicola SerraDepartment of Neuroscience, Reproductive Sciences and Dentistry - Audiology Section, University of Naples Federico II, Naples, Italy.ORCID 0000-0001-8086-6362
Michela ButtàDepartment of Health Promotion, Mother and Child Care, Internal Medicine, Medical Specialties (PROMISE) G. D'Alessandro, University of Palermo, Palermo, Italy.ORCID 0000-0002-2410-8759
Leonardo Di GregorioUrology Unit, University Hospital Policlinic, P. Giaccone, Palermo, Italy.
Manfredi Del SordoDepartment of Health Promotion, Mother and Child Care, Internal Medicine, Medical Specialties (PROMISE) G. D'Alessandro, University of Palermo, Palermo, Italy.
Daniela PistoiaMicrobiology and Virology Unit, University Hospital Policlinic, P. Giaccone, Palermo, Italy.
Alberto FirenzeDepartment of Health Promotion, Mother and Child Care, Internal Medicine, Medical Specialties (PROMISE) G. D'Alessandro, University of Palermo, Palermo, Italy.
Maurizio SoresiDepartment of Health Promotion, Mother and Child Care, Internal Medicine, Medical Specialties (PROMISE) G. D'Alessandro, University of Palermo, Palermo, Italy.ORCID 0000-0001-7850-555X
Gabriele TuloneUrology Unit, University Hospital Policlinic, P. Giaccone, Palermo, Italy.
Giuseppina CapraDepartment of Health Promotion, Mother and Child Care, Internal Medicine, Medical Specialties (PROMISE) G. D'Alessandro, University of Palermo, Palermo, Italy.ORCID 0000-0002-1407-7282

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV) represents the most prevalent sexually transmitted infection worldwide, often presenting as asymptomatic or subclinical in males. There is still uncertainty about the most suitable biological specimen for an accurate HPV diagnosis in males since the sampling site influences the performance of the diagnosis. Conventional diagnostic strategies rely on uncomfortable specimens for patients, such as urethral swabs. This study aimed to evaluate the diagnostic performance of using non-invasive, self-collected urine samples as an alternative to urethral swabs for detecting HPV infections in men. A total of 110 men provided a genital swab, a urethral swab, and a urine sample for analysis. HPV DNA was detected in 74.5% of the total samples, with 89.0% of HPV-positive samples harboring at least one oncogenic genotype. The most frequently detected genotypes were HPV53, HPV66, and HPV16. Of the individual specimens examined, genital swabs demonstrated the highest HPV positivity rate (68.2%), significantly outperforming urethral swabs and urine samples (

Indexed as

Human Papillomavirus VirusesPapillomaviridaePapillomavirus InfectionsUrineAdultDNA, ViralGenotypeHumansMaleMiddle AgedSensitivity and SpecificitySpecimen HandlingUrethraYoung AdultDNA, Viralgenital swabHPVHPV non-invasive diagnosishuman papillomavirusmaleurine

Identifiers

PMID42345566
PMCPMC13436416

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.