Evidence map›Paper›PMID 42345523›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

The nuclear receptor ROR-alpha is a putative novel myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor.

Raghu Sundaresan Nagalingam, Ju Youn Beak, Richard D Lutze, Wei Huang, Dhiren Akkina, Christina Kang, Anyue Zhao, Britney G Alcira, Amir Aghajanian, Kevin E Gerrish and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Raghu Sundaresan NagalingamMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.
Ju Youn BeakMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.
Richard D LutzeMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.ORCID 0009-0007-3410-8182
Wei HuangMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.
Dhiren AkkinaMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.ORCID 0009-0005-1207-4685
Christina KangMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.
Anyue ZhaoMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.
Britney G AlciraMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.
Amir AghajanianDivision of Cardiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.
Kevin E GerrishMolecular Genomics Core Laboratory, National Institute of Environmental Health Sciences, Durham, North Carolina, United States.
Hong Soon KangImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States.
Anton M JettenImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States.ORCID 0000-0003-0954-4445
Brian C JensenMcAllister Heart Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.ORCID 0000-0001-6430-8344

Funding

Metabolic mechanisms of cardioprotection through alpha-1A adrenergic receptor activationR01HL140067 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian C Jensen · 2018 to 2026
$4.2M
Nuclear receptors--Action, functions, &roles in diseaseZ01ES101586 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JETTEN, ANTON M · 2003 to 2008
$3.2M
Canadian Institutes of Health Research (CIHR) FRN 187866HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 2R01HL140067HHS | NIH | National Institute of Environmental Health Sciences (DEHS) Z01-ES-101586Intramural NIH HHS Z01 ES101586NHLBI NIH HHS R01 HL140067
6 · The paper itself

Abstract

We recently found that the nuclear receptor retinoic acid-related orphan nuclear receptor alpha (RORα) protects against angiotensin II-induced cardiac hypertrophy and promotes cardiomyocyte mitophagy. The target genes for this ligand-activated transcriptional coregulator have not been defined in the heart. We used RNA microarrays to profile the cardiac transcriptomes of "staggerer" (

Indexed as

Myocytes, CardiacNuclear Receptor Subfamily 1, Group F, Member 1Receptors, Adrenergic, alpha-1TranscriptomeAnimalsCells, CulturedMaleMiceMice, Inbred C57BLMice, KnockoutPromoter Regions, GeneticTranscription, GeneticAdra1a protein, mouseNuclear Receptor Subfamily 1, Group F, Member 1Receptors, Adrenergic, alpha-1Rora protein, mouseadrenergic alphamuscle developmentnuclear receptor ROR-alphareceptorstranscriptome

Identifiers

PMID42345523
PMCPMC13374567

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.