ArticleJACC. Case reports2026
Transcatheter Edge-to-Edge Repair in a Patient With Severe Degenerative Mitral Regurgitation and Mirror-Image Dextrocardia.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
backgroundManaging severe degenerative mitral regurgitation (MR) in patients with mirror-image dextrocardia is challenging given the rare, complex anatomy. Transcatheter edge-to-edge repair (TEER) offers a minimally invasive alternative for patients at high surgical risk. CASE SUMMARY: A 76-year-old woman with dextrocardia presented with NYHA functional class III heart failure due to severe MR from anterior leaflet flail. Given prohibitive surgical risk, she successfully underwent TEER with 2 MitraClip XTR devices. Adaptations for the mirrored anatomy included a modified transseptal puncture site and reversed catheter maneuvering. Postprocedural MR was reduced to trivial without stenosis, with rapid symptomatic improvement. DISCUSSION: This case confirms the feasibility of TEER for degenerative MR in dextrocardia. TAKE-HOME MESSAGE: TEER for degenerative MR in dextrocardia is critically dependent on preprocedural planning and specific intraoperative modifications to accommodate the reversed anatomy, expanding minimally invasive options for high-risk patients with complex cardiac conditions.
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