ArticleFrontiers in cellular and infection microbiology2026
EndoNUclease Heteroduplex cleavage typing a new technique for rapid typing of bacterial isolates in the context of nosocomial outbreaks: proof of concept with
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: This study evaluates the EndoNUclease Heteroduplex Cleavage Typing (ENUHCT) as a rapid alternative to MLST for Results: ENUHCT demonstrated high discriminatory power, with strains sharing identical STs showing no cleavage, while strains with differing STs exhibited distinct cleavage patterns. Phylogenetic analysis based on ENUHCT data closely matched MLST-derived trees, highlighting its potential for real-time outbreak tracking. However, ENUHCT's accuracy decreased with high Single Nucleotide Polymorphisms (SNP) counts (≥4), as peak detection became less reliable. Despite this limitation, ENUHCT proved effective for initial strain screening, reducing the need for full genome sequencing in unrelated strains. Conclusion: In conclusion, ENUHCT offers a rapid, cost-effective alternative to MLST for
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