Evidence map›Paper›PMID 42345001›Full record

ArticleJournal of inflammation research2026

Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury.

Lin Tu, Yuming Lu, Xingde Liu, Xiangchun Shen

Abstract read
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Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lin TuDepartment of Cardiology Vascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550000, People's Republic of China.
Yuming LuDepartment of Cardiology Vascular Medicine, The First People's Hospital of Guiyang, Guiyang, 550000, People's Republic of China.
Xingde LiuDepartment of Cardiology Vascular Medicine, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550000, People's Republic of China.
Xiangchun ShenGuizhou International Science & Technology Cooperation Base for Druggability Research of Natural Medicines, Guizhou Medical University, Guizhou, 561113, People's Republic of China.ORCID 0000-0002-4333-9106

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Salvianic acid A, known for its potent cardioprotective effects, is a promising therapeutic agent for myocardial ischemia-reperfusion (I/R) injury, a condition where ferroptosis plays a critical role. This study aims to explore the effect of Salvianic acid A on I/R injury through EGFR-Nrf2-GPX4-mediated ferroptosis. Methods: The levels of ROS, GSH, GSSG, Fe Results: Salvianic acid A inhibited ROS, Fe Conclusion: Salvianic acid A mediated ferroptosis through the EGFR-regulated NRF2-GPX4 pathway, ultimately improving myocardial I/R injury.

Indexed as

EGFRferroptosismyocardial ischemia-reperfusion injuryNrf2-GPX4Salvianic acid A

Identifiers

PMID42345001
PMCPMC13289659

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.