Evidence map›Paper›PMID 42344951›Full record

Article... International Conference on Manipulation Automation and Robotics at Small Scales (MARSS). International Conference on Manipulation Automation and Robotics at Small Scales2024

Peanut Shaped Microrobots for Anticancer Therapy.

Neda K Dezfuli, Andrés F Flórez, Saray Gallo, David P Rivas, Sambeeta Das

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ... International Conference on Manipulation Automation and Robotics at Small Scales (MARSS). International Conference on Manipulation Automation and Robotics at Small Scales, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Neda K DezfuliDepartment of Mechanical Engineering at the University of Delaware, Newark.
Andrés F FlórezDepartment of Systems Biology at Harvard Medical School.
Saray GalloDepartment of Systems Biology at Harvard Medical School.
David P RivasDepartment of Mechanical Engineering at the University of Delaware, Newark.
Sambeeta DasDepartment of Mechanical Engineering at the University of Delaware, Newark.

Funding

The eye as a window into sickle cell disease morbidityP20GM109021 · NIGMS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI HILDENBRAND, AIMEE K · 2014 to 2025
$20.7M
Controlling Cellular Fate using MicromachinesR35GM147451 · NIGMS · UNIVERSITY OF DELAWARE · PI Sambeeta Das · 2022 to 2026
$2.0M
NIGMS NIH HHS P20 GM109021NIGMS NIH HHS R35 GM147451
6 · The paper itself

Abstract

iron nanoparticles have been used in cancer research for their anticancer activity. The mechanism of action for this activity tends to be ferroptosis. Inspired by this we made hematite based peanut shaped microrobots and demonstrated their anticancer activity. We examined how peanut-shaped microrobots impacted HT1080 cancer cell lines, aiming to understand the mechanism behind cell death. Surprisingly, we discovered that unlike iron particles, these specific microrobots did not trigger ferroptosis. Additionally, when we tried to understand the mechanism behind the cell death by using ferroptosis inhibitors, they did not rescue the cells from death as expected. These results suggest that the cytotoxic effects of peanut-shaped microrobots on HT1080 cells may involve alternative pathways rather than ferroptosis.

Identifiers

PMID42344951
PMCPMC13290113

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.