SynthesisFrontiers in immunology2026
Cross-species systems analysis distinguishes inflammatory remodeling from primary mucus secretory failure in inflammatory bowel disease.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Intestinal mucus and epithelial barrier dysfunction are central features of inflammatory bowel disease (IBD), yet the regulatory mechanisms underlying mucus disruption remain inconsistent across individual studies. Anterior gradient 2 ( Methods: We performed a meta-analysis of 26 independent human colonic transcriptomic datasets comprising 1,302 active, untreated samples to derive a consensus mucus-barrier regulatory program in Crohn's disease (CD) and ulcerative colitis (UC). Random-effects modeling identified differentially expressed genes, which were evaluated using gene set enrichment for biological processes relevant to mucus regulation. To provide a mechanistic benchmark for primary secretory failure, we generated an orthogonal colon proteome from Results: Across human cohorts, 3,129 genes in CD and 3,729 in UC were differentially expressed, with substantial overlap between diseases. Both conditions showed coordinated upregulation of pathways linked to goblet-cell differentiation, mucin transcription, post-translational glycosylation, secretion, microbial sensing, and endoplasmic reticulum quality control. Discussion: Cross-species comparison revealed convergence between IBD and
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.