ArticleFrontiers in nutrition2026
Frailty and sarcopenia as independent predictors of early functional recovery in older adults with osteoporotic vertebral compression fractures: a retrospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The high burden of functional and chronic disability in older adults due to osteoporotic vertebral compression fractures (OVCFs) reflects both fracture characteristics and patient-related factors influencing recovery. The underlying conditions that define frailty and sarcopenia, or the inability of osteoporotic patients to maintain muscle mass, may have an important role in functional recovery after OVCF. Methods: In this retrospective cohort study, 120 patients aged ≥60 years who were diagnosed with radiologically confirmed OVCFs and underwent treatment in a tertiary care center from January 2020 to December 2023 were included. Patients were stratified based on sarcopenia and frailty. The primary outcome of interest was functional recovery, as measured by the Barthel Index at discharge; secondary outcomes included length of hospital stay, complications, VAS pain score, and hospital-based complications. Multivariable linear regression of functional recovery on the independent variables was then calculated. The primary endpoint reflects early in-hospital functional recovery and does not capture long-term outcomes. Results: Compared to non-frail patients, frail individuals had lower Barthel Index scores (65.3 ± 12.4 vs. 82.5 ± 10.2, Conclusion: Frailty and sarcopenia were independently associated with reduced early functional recovery in older adults with osteoporotic vertebral compression fractures. These findings highlight the potential importance of incorporating geriatric and muscle health assessments into clinical evaluation; however, further prospective studies are required to confirm these associations.
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