Evidence map›Paper›PMID 42344806›Full record

ReviewFrontiers in neural circuits2026

Functional implications of atypical action potential generation in the (patho)physiological brain: from developmental program to glioma.

Tong Tong, Anders Rosendal Korshøj, Wen-Hsien Hou

Abstract readReview
In one paragraph

Review in Frontiers in neural circuits, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tong TongDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Anders Rosendal KorshøjDepartment of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Wen-Hsien HouDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical action potentials (aAPs) are fast depolarizing electrical spikes recorded from the cell body, with a smaller amplitude. Despite varying in the generating mechanisms, aAPs have been reported in various brain cell types, including neurons, oligodendrocyte precursor cells (OPCs), and glioma cells. In this mini-review, we summarize the mechanisms and physiological functions of aAPs and outline their contributions to neurological diseases, particularly in glioma pathology. aAPs have been observed in mature brains, arising from mechanisms such as ectopic depolarizations and gap junction coupling, thereby supporting synaptic integration and network synchrony. It is also a signature of immature neurons in development. Subsets of NG2

Indexed as

Action PotentialsBrainBrain NeoplasmsGliomaNeuronsAnimalsHumansatypical action potentialsgliomaintrinsic excitabilityneurodevelopmentneuron–glioma interactionoligodendrocyte precursor cellspatch-clampspikelets

Identifiers

PMID42344806
PMCPMC13286902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.