ReviewFrontiers in neural circuits2026
Functional implications of atypical action potential generation in the (patho)physiological brain: from developmental program to glioma.
Review in Frontiers in neural circuits, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Atypical action potentials (aAPs) are fast depolarizing electrical spikes recorded from the cell body, with a smaller amplitude. Despite varying in the generating mechanisms, aAPs have been reported in various brain cell types, including neurons, oligodendrocyte precursor cells (OPCs), and glioma cells. In this mini-review, we summarize the mechanisms and physiological functions of aAPs and outline their contributions to neurological diseases, particularly in glioma pathology. aAPs have been observed in mature brains, arising from mechanisms such as ectopic depolarizations and gap junction coupling, thereby supporting synaptic integration and network synchrony. It is also a signature of immature neurons in development. Subsets of NG2
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