Evidence map›Paper›PMID 42344805›Full record

ArticleFrontiers in pharmacology2026

A novel prenylflavonoid with efficacy in cancer therapy by targeting ceramide-orchestrated signaling.

Ruichen Du, Cui Zhang, Hehua Lei, Xin Gao, Qingwei Xiang, Zhiwen Zhang, Yongping Dai, Xinzhi Li, Limin Zhang, Gang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruichen DuState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, CAS, Wuhan, China.
Cui ZhangState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, CAS, Wuhan, China.
Hehua LeiState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, CAS, Wuhan, China.
Xin GaoState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, CAS, Wuhan, China.
Qingwei XiangHubei Shizhen Laboratory, Department of Geriatrics, Hubei University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Zhiwen ZhangHubei Shizhen Laboratory, Department of Geriatrics, Hubei University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Yongping DaiThe First Affiliated Hospital of Ningbo University, Ningbo, China.
Xinzhi LiSchool of Pharmacy, Faculty of Medicine, Laboratory for Drug Discovery from Natural Resource, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, China.
Limin ZhangState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, CAS, Wuhan, China.
Gang ChenHubei Shizhen Laboratory, Department of Geriatrics, Hubei University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ceramide, acting as an important second messenger, plays a pivotal role in the induction of apoptosis in cancer cells. As one of the active prenylflavonoid ingredients in Purpose: This study aimed to analyze the potential mechanism of GH01 for cancer therapy by generating ceramide formation Methods: A B16F10 melanoma-bearing mouse model was first established and treated with GH01 at different doses. Targeted quantification of ceramide was performed Results: GH01 treatment markedly enhanced ceramide levels through the activation of ceramide

Indexed as

cancer therapycell apoptosisceramideicariside Imetabolomics

Identifiers

PMID42344805
PMCPMC13287425

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.