ArticleAsian journal of transfusion science
Analysis of risk factors for red blood cell alloimmunization and its incidence in hemoglobinopathy patients at a tertiary care center in Odisha, Eastern India.
Article in Asian journal of transfusion science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSickle cell disease (SCD) and thalassemia are common hemoglobinopathies in Eastern India. Regular blood transfusion in these patients leads to alloimmunization. Finding compatible red blood cell units remain a challenge in these patients delaying the transfusion support.
aimsThis study aims to estimate the frequency of alloimmunization and predicts the associated risk factors. METHODOLOGY: A retrospective study was conducted for 2 years. Data were retrieved from the immunohematology work-up record. The Chi-square statistics determined the risk factors associated with alloimmunization. Multivariate regression analysis was used to identify independent risk factors of alloimmunization, adjusting the confounders. A
resultsForty-seven patients out of 132 developed antibodies. Of these, 41 presented with only alloantibodies, three patients had only autoantibodies, and the rest 3 had both autoantibodies and alloantibodies. Most commonly observed alloantibodies were against Rh, Kidd, Duffy, and S antigens. SCD appeared a significant risk factor for the development of alloimmunization in the Chi-square test (
conclusionWe found a high incidence of alloimmunization in multitransfused hemoglobinopathies patients in this region. This study also shows the first transfusion at an age of more than 2 years and up to 10 transfusions are independent predictors of alloimmunization.
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