Evidence map›Paper›PMID 42344551›Full record

ReviewFrontiers in dental medicine2026

Clear aligner therapy beyond esthetics: oral health, polymer materials, and the environmental cost of digital orthodontics.

Javier Iván Martínez-Hernández, Carlos Esteban Villegas-Mercado, Sandra Aidé Santana-Delgado, Grissel Guadalupe Orozco-Molina, Juan Antonio Arreguín-Cano, Karina Ordóñez-Torres, Manuel Antonio Luján-Aguilar, Laura Isabel Duarte-Chávez, Adolfo González-Acosta, Cecilia Casavantes-Lazo and 2 more

Abstract readReview
In one paragraph

Review in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Javier Iván Martínez-HernándezFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Carlos Esteban Villegas-MercadoFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Sandra Aidé Santana-DelgadoFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Grissel Guadalupe Orozco-MolinaFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Juan Antonio Arreguín-CanoFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Karina Ordóñez-TorresAnáhuac University Querétaro, Querétaro, Mexico.
Manuel Antonio Luján-AguilarFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Laura Isabel Duarte-ChávezFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Adolfo González-AcostaFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Cecilia Casavantes-LazoFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Claudia Ivette Bujanda-RíosFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.
Mercedes BermúdezFaculty of Dentistry, Autonomous University of Chihuahua, Chihuahua, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear aligner therapy (CAT) has become a popular orthodontic option, driven by advances in digital workflows, increasing aesthetic demands, and perceived benefits in comfort and oral hygiene. Although its clinical effectiveness has been well documented, a thorough review of its biological and environmental effects remains incomplete. This narrative review consolidates current evidence on CAT, exploring their history, material makeup, impact on oral health, and emerging environmental concerns. Recent clinical and microbiological research indicates that CAT may improve plaque control and periodontal health compared with fixed appliances; however, these benefits are heavily influenced by patient behavior, baseline caries risk, treatment duration, and adherence to hygiene and dietary guidelines. Evidence shows that aligner materials can support bacterial and fungal biofilm growth and, under certain conditions, may lead to enamel demineralization or erosion, emphasizing the need for personalized risk assessments and proper aligner maintenance. From a materials standpoint, modern aligners are primarily made from thermoplastic and polyurethane polymers, designed to exert controlled orthodontic forces and ensure durability. While beneficial clinically, these materials are poorly degradable and have limited recyclability. Life cycle analyses reveal that the environmental impact of CAT extends beyond disposal to include polymer production, energy-intensive manufacturing, packaging, and distribution. Additionally, emerging research suggests that aligners may release microplastics during use, adding to concerns about plastic pollution beyond solid waste. Given the rapid growth of the global clear aligner market, even small amounts of material per patient can result in a significant environmental impact. Overall, the evidence indicates that clear aligner therapy involves a complex interplay among biomechanics, patient care, materials science, and environmental sustainability. An integrated, life-cycle-based strategy is crucial to guiding clinicians, researchers, and manufacturers toward treatments that are both effective and environmentally responsible.

Indexed as

clear aligner therapydigital orthodonticsenvironmental sustainabilitylife cycle assessment (LCA)microplasticsoral microbiomeorthodontic alignerspolymer-based biomaterials

Identifiers

PMID42344551
PMCPMC13287105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.