SynthesisFrontiers in medicine2026
Intensive versus conventional phototherapy for neonatal hyperbilirubinemia: a systematic review and meta-analysis of RCTs and cohort studies.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The clinical efficacy of intensive phototherapy for neonatal hyperbilirubinemia remains inconsistently reported across studies. Method: The meta-analysis was conducted in accordance with PRISMA 2020 and MOOSE guidelines. We searched Web of Science, PubMed, Embase, and ScienceDirect for eligible comparative studies from the inception of the databases up to March, 2026. The primary outcome was the reduction in total serum bilirubin (TSB) levels from baseline to the completion of phototherapy, and the duration of phototherapy was defined as the secondary outcome. The pooled results were synthesized via random-effect model. Influential publication was determined by performing sensitivity analysis. In addition, the potential sources of heterogeneity were examined by using subgroup analyses. Publication bias was assessed using the funnel plot, Begg's and Egger's tests. Result: The 12 included studies (8 RCTs and 4 cohort studies) published between 1995 and 2026, enrolling 1,144 neonates with mean gestational age ranging from 30 to 39 weeks and baseline TSB levels from 172 to 390 μmol/L. Intensive phototherapy achieved significantly greater TSB reductions compared to conventional phototherapy within the same timeframe (MD = -21.87, 95% CI = -29.69 to -14.05, Conclusion: Phototherapy has been established as the cornerstone of clinical management for neonatal hyperbilirubinemia. Intensive phototherapy demonstrates superior clinical efficacy in reducing TSB levels and treatment duration than conventional phototherapy, especially in preterm neonates with severe hyperbilirubinemia. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261324708, Identifier CRD420261324708.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.