ArticleFrontiers in medicine2026
Impact of clinical pharmacist-led medication management and education on tacrolimus therapeutic control.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The management of Tacrolimus in pediatric bone marrow transplantation (BMT) presents significant challenges owing to its narrow therapeutic index and considerable pharmacokinetic variability. This study assesses the effects of clinical pharmacist interventions, particularly the resolution of drug-related problems (DRPs) and caregiver and nursing staff education, on stabilizing tacrolimus blood concentrations. Methods: This prospective interventional study was conducted across five hospitals in Istanbul from June 2024 to January 2026. The study comprised 65 pediatric patients, their caregivers, and 50 nurses. Clinical pharmacists identified Drug-Related Problems (DRPs) utilizing the PCNE V9.00 system and delivered both verbal and written educational interventions. Knowledge assessments and tacrolimus levels were evaluated at baseline, post-education, and at the 3-month follow-up. Results: Out of the 35 pharmacist interventions conducted, 77.1% were successfully resolved. The proportion of patients within the therapeutic range (5-20 ng/ml) increased from 52.3% at baseline to 84.4% following the educational intervention and remained at 82.5% after 3 months ( Discussion: Clinical pharmacist-led interventions substantially improve the management of tacrolimus therapy in pediatric bone marrow transplantation. Systematic education and proactive resolution of drug-related problems are essential for optimizing medication levels and safeguarding patient safety by addressing critical behavioral and systemic factors in post-transplant management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.