ArticleAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2026
Long-Term Outcomes After Multiorgan Resection of Primary Gastrointestinal Stromal Tumors.
Article in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Complete resection is the mainstay of therapy for nonmetastatic gastrointestinal stromal tumors (GIST) and may necessitate multiorgan resection (MOR). We evaluated surgical oncological outcomes as well as long-term quality of life (QoL) in patients undergoing MOR or single-organ resection (SOR) for primary GIST. Methods: One hundred fifty-two primary GIST resections performed at Heidelberg University Hospital (2002-2022) were retrospectively analyzed, including subgroup analyses for locally advanced GIST (T3/T4, n = 76). Kaplan-Meier and multivariable Cox regression analyses assessed overall survival (OS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS). QoL was evaluated using standardized questionnaires (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30, Warwick-Edinburgh Mental Well-Being Scale, Fear of Progression Questionnaire, and Primary Care PTSD Screen). Results: One hundred two (67.1%) patients with primary GIST underwent SOR, and 50 (32.9%) underwent MOR. Five-year OS was 87% in the SOR and 95% in the MOR group. Patients in the MOR group exhibited tumors with higher Armed Forces Institute of Pathology risk scores ( Conclusions: MOR is comparable to SOR regarding OS, despite patients undergoing MOR having more prognostically unfavorable tumors. While MOR is associated with increased postoperative morbidity, long-term QoL remains unaffected. Thus, MOR appears oncologically effective when necessary in certain clinical scenarios and does not compromise long-term patient-reported QoL.
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