Evidence map›Paper›PMID 42344385›Full record

ArticleEndoscopy international open2026

Efficacy of gel immersion endoscopic submucosal dissection for colorectal lesions.

Ken Inoue, Naohisa Yoshida, Reo Kobayashi, Takeshi Yasuda, Naoto Iwai, Osamu Dohi, Kazuhiko Uchiyama, Yuri Tomita, Ryohei Hirose, Hardesh Dhillon and 1 more

Abstract read
In one paragraph

Article in Endoscopy international open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ken InoueMolecular Gastroenterology and HepatologyGraduate School of Medical Science, Kyoto Prefectural University of MedicineKyotoJapan.ORCID 0000-0002-6383-0576
Naohisa YoshidaMolecular Gastroenterology and HepatologyGraduate School of Medical Science, Kyoto Prefectural University of MedicineKyotoJapan.ORCID 0000-0001-6167-9705
Reo KobayashiMolecular Gastroenterology and HepatologyGraduate School of Medical Science, Kyoto Prefectural University of MedicineKyotoJapan.
Takeshi YasudaMolecular Gastroenterology and HepatologyGraduate School of Medical Science, Kyoto Prefectural University of MedicineKyotoJapan.ORCID 0000-0002-7387-7511
Naoto IwaiMolecular Gastroenterology and HepatologyGraduate School of Medical Science, Kyoto Prefectural University of MedicineKyotoJapan.
Osamu DohiMolecular Gastroenterology and HepatologyGraduate School of Medical Science, Kyoto Prefectural University of MedicineKyotoJapan.ORCID 0000-0002-0498-0144
Kazuhiko UchiyamaMolecular Gastroenterology and HepatologyGraduate School of Medical Science, Kyoto Prefectural University of MedicineKyotoJapan.
Yuri TomitaDepartment of GastroenterologyKyoto Hakuaikai HospitalKyotoJapan.ORCID 0000-0003-3244-6894
Ryohei HiroseDepartment of Infectious DiseaseKyoto Perfectural University of MedicineKyotoJapan.
Hardesh DhillonDepartment of GastroenterologyBarwon HealthVictoriaAustralia.ORCID 0000-0003-2258-0950
Tomohisa TakagiMolecular Gastroenterology and HepatologyGraduate School of Medical Science, Kyoto Prefectural University of MedicineKyotoJapan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and study aims: Endoscopic submucosal dissection (ESD) for colorectal lesions has become widely accepted but remains technically demanding, with perforation risk related to luminal distension and suboptimal visualization. Gel immersion ESD (GI-ESD) may offer mechanistic advantages over conventional CO Patients and methods: In this single-center retrospective study, 426 consecutive colorectal ESD cases (from January 2022 to December 2024) were analyzed. C-ESD was performed from January 2022 to March 2024; GI-ESD using Viscoclear (Otsuka Pharmaceutical Factory, Tokushima, Japan) from April to December 2024. After excluding non-epithelial lesions, 392 patients were included, including interrupted procedures. The primary outcome was adverse events (perforation, delayed bleeding). Secondary outcomes were en bloc and R0 resection rates, procedure time, and postoperative inflammatory response. Results: Of 392 patients, 293 underwent C-ESD and 99 underwent GI-ESD were analyzed. En-bloc and R0 resection rates were comparable between GI-ESD and C-ESD (97.0% vs. 99.9%, Conclusions: GI-ESD achieved curative outcomes comparable to C-ESD while reducing perforation risk; PECS remained comparable between groups.

Indexed as

Colorectal cancerEndoscopic resection (polypectomy, ESD, EMRc, ...)Endoscopy Lower GI TractPerformance and complicationsQuality and logistical aspects

Identifiers

PMID42344385
PMCPMC13289959

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.