Evidence map›Paper›PMID 42344277›Full record

ArticleNature health2026

Metabolomic signatures of dietary carbohydrates and differential association with type 2 diabetes.

Xiaowen Wang, Pengfei Xia, Fenglei Wang, Zhiyuan Wu, Yang Hu, A Heather Eliassen, Oana A Zeleznik, Shilpa N Bhupathiraju, Seyed Mohammad Mousavi, Ross L Prentice and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Xiaowen WangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Pengfei XiaDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Fenglei WangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Zhiyuan WuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Yang HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
A Heather EliassenDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Oana A ZeleznikChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
Shilpa N BhupathirajuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Seyed Mohammad MousaviDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ross L PrenticeCancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Lesley F TinkerCancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cheng ZhengDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA.
Simin LiuDepartment of Epidemiology and Biostatistics, The Joe C Wen School of Population & Public Health; Division of Cardiology, Department of Medicine, School of Medicine, The University of California, Irvine (UCI), CA USA.
Ying HuangBiostatistics Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sandi L NavarroCancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Mary C PlaydonDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, and Huntsman Cancer Institute, Salt Lake City, UT, USA.
Steven C MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Linda SnetselaarUniversity of Iowa School of Public Health, Iowa City, IA, USA.
Fred K TabungDepartment of Internal Medicine, Division of Medical Oncology, College of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
JoAnn E MansonChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
Lihong QiDepartment of Public Health Sciences, The University of California Davis, Davis, CA, USA.
Daniel RafteryNorthwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA.
Walter C WillettDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Johanna W LampeCancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Marian L NeuhouserCancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Qi SunDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON · 1986 to 2026
$30.4M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Nutrition and Physical Activity Assessment Study (NPAAS)R01CA119171 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian L Neuhouser · 2006 to 2026
$14.3M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0M
Metabolomics Core for the Dietary Biomarkers Development Center at Harvard UniversityU2CDK129670 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI SUN, QI · 2021 to 2025
$7.0M
NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA119171NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL060712NIA NIH HHS R21 AG070375NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK119268NIDDK NIH HHS R01 DK120870NIDDK NIH HHS R01 DK126698NIDDK NIH HHS U2C DK129670NIEHS NIH HHS R01 ES022981NIEHS NIH HHS R01 ES036206WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

Metabolomic indices summarizing diet-related metabolic responses are instrumental for examining and replicating diet-disease associations. We aimed to identify metabolomic signatures characterizing the amounts and types of dietary carbohydrates and assess their associations with type 2 diabetes (T2D) risk. Nutritional metabolomics indices were developed using data from 1,196 healthy participants in the Lifestyle Validation Studies (LVS) with 7-day diet records (7DDRs). Elastic net regression within cross-validation was used to derive metabolomic indices of total carbohydrates and primary food sources. Replication was conducted using feeding menu data among 153 women from the Nutrition and Physical Activity Assessment Study (NPAAS). Associations with incident T2D were examined using multivariable Cox regression in 11,454 participants from the Nurses' Health Study (NHS), NHSII, and Health Professionals Follow-up Study. Metabolites positively associated with total carbohydrates and added sugars mainly included glycerolipids (DAGs, TAGs), while glycerophospholipids (PEs, PCs) were inversely associated. Whole grains were linked to betaine, 3-indolepropionic acid (IPA), and hippuric acid; vegetables and legumes to IPA, N-acetylornithine, and pipecolic acid; and fruits to proline-betaine and IPA. Identified metabolomic signatures showed significant correlations with 7DDR-assessed diet in the LVS (Pearson

Identifiers

PMID42344277
PMCPMC13290266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.