ArticleOrganic process research & development2026
Scaling Up Is Not the Same but Bigger: Overcoming (Some) Limitations in Enzymatic Decarboxylations in Rotating Bed Reactors in Deep Eutectic Solvents.
Article in Organic process research & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Deep eutectic solvents (DESs) can be designed to be enzyme-compatible and substrate solubilizers. Most biocatalytic reactions in DESs are conducted at small scale, and assessing how to scale up DES-based enzymatic reactions is necessary to assess their feasibility and associated challenges. This work studies the viability of using DESs with a phenolic acid decarboxylase (PAD) to synthesize 4-vinylguaiacol (4-VG) from ferulic acid. Upon PAD immobilization, the reaction is performed in a betaine-glycerol DES (1:2) with 20 vol % buffer in a rotating bed reactor (RBR) at the 120 mL scale. Full conversion of 300 mM ferulic acid (∼58 g/L) is achieved within 18 h at the 10 mL scale. However, challenges a substrate loadings are intended (1 M ferulic acid, ∼200 g/L) in the RBR at 120 mL, where ∼60% conversion is obtained, with a productivity of ∼10 g product/L/h. The formation of CO
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